close

Prescription drugs

Prescription drugs

The future of the safe harbor for prescription drugs remains uncertain

In November 2020, four months after the Trump administration issued a series of executive orders reiterating its policy goals on reducing costs for consumers of prescription drugs and leading the Department of Health and Human Services, Office of the Inspector General (“HHS-OIG”) to implement these policy objectives, the HHS-OIG has issued a Final rule to amend certain provisions of the Safe Harbor regulation under the Federal Anti-Recoil Act (“AKS”). The final rule included three key provisions:

  1. Removal Safe Harbor protection for manufacturer discounts paid directly or indirectly through a Pharmacy Benefits Manager (“PBM”) to Medicare Part D or Medicare Advantage plans (the “Discount Rule”). “);
  2. Creation of a new safe harbor to protect point-of-sale (“POS”) price reductions paid by manufacturers to Medicare Part D plans, Medicare Advantage plans and Medicaid managed care organizations (“MCO”); and
  3. Creation of a new safe harbor to protect the fair market value (FMV) service fees paid to PBMs by manufacturers.

The final rule imposed an effective date of January 1, 2022 for the discount rule. However, in January 2021, two months after the final rule was issued and in a lawsuit by the Pharmaceutical Care Management Association challenging the surrender rule, the Biden administration agreed to postpone the entry date. in force of the discount rule on January 1, 2023, as reflected in a Order by the United States District Court for the District of Columbia.

In the meantime, however, Congress passed the Law on investment in infrastructure and employment (the “Infrastructure Act”). This law, signed by President Biden on November 15, 2021, further delayed the implementation of the discount rule until January 2026. Thus, the rule, which many believed would be removed as part of the payment of the cost of the infrastructure bill, was still alive, if only delayed until the middle of the next presidential term.

Then, on November 19, 2021, the House of Representatives adopted the Rebuild Better Act (“BBBA”), which included the last nail in the coffin of the ruler. Section 139301 of this bill stated that the HHS-OIG “shall not implement, administer or enforce” any of the provisions of the rule. This was the total repeal that had been provided for in the previous law.

The bill went to the Senate before Thanksgiving and was to go through a reconciliation process that is exempt from Senate filibuster rules and would only have required all 50 Democratic and Independent Senators to vote for, the Deputy Speaker Kamala Harris playing the tiebreaker role. 51st vote in favor of the bill. However, Senator Joe Manchin (D – W. Va.) Recently announced his opposition to the bill, and his vote could prevent the bill from being passed. If the BBBA is not passed by the Senate, its ban on implementing the final rule will fail with it, and unless any further action is taken, the discount rule will take effect in January 2026.

As a result, it is not clear until the Senate took action in January whether PBMs, MCOs, Part D plans and Medicare Advantage plans will need to worry about these changes to the anti-rollback provisions. . If the Senate does not pass the bill, then all of these entities should begin reviewing their policies and procedures over the next four years in preparation for the rule coming into force.

Reed Smith will continue to monitor developments related to the discount rule and its impact on the industry.

read more
Prescription drugs

Marijuana, Many Prescription Drugs Lead to Impaired Driving Chroniclers

December is National Impaired Driving Prevention Month. You’ve probably heard all about the dangers of drunk driving, but do you know the dangers of drunk driving? Driving under the influence of over-the-counter drugs, prescription drugs, marijuana, or any other mind-altering medication makes it dangerous to drive a vehicle.

Unfortunately, research indicates that the prevalence of the drug is on the rise among drivers. According to the trauma centers studied from October to December 2020, 56% of drivers involved in serious injuries or fatalities have tested positive for at least one drug.

How common is drug-impaired driving? After alcohol, marijuana is the most commonly used drug while driving. In 2020, 12.6 million people (aged 16 and over) are believed to have driven after using illicit drugs. Of that total, 11.7 million people were under the influence of marijuana. In another recent survey, 22% of teens admitted that driving with heavy marijuana use is common among their friends. 3.6 million young people between the ages of 16 and 25 admit to having driven under the influence of marijuana in the past year, according to the 2020 National Survey on Drug Use and Health. These statistics are of great concern, given that drugs such as marijuana affect the way people drive, endangering drivers, their passengers and others on the road. Drugs can affect a driver’s perception, attention, balance, coordination, reaction time, and other skills they need to stay alert and safe.

The National Highway Traffic Safety Administration’s Drug and Alcohol Crash Risk Study found that marijuana users are more likely to be involved in crashes. However, the increased risk may be due in part to the fact that marijuana users are more likely to be young men, who are generally at higher risk for accidents. Either way, research shows that marijuana slows reaction time, impairs driver focus and attention, and reduces hand-eye coordination. The THC in marijuana also interferes with a driver’s ability to multitask, an essential skill necessary for people behind the wheel.

Impaired driving can also occur after using prescription or over-the-counter medications such as cough suppressants, antihistamines, sleeping pills, and anti-anxiety medications. In some cases, even small amounts of these substances can impair driving skills by impairing perception, mental processes, attention, balance, coordination and other skills required for safe driving. For this reason, many prescription drugs have warning labels that advise against using machines and driving motor vehicles for a period of time after use.

Car crashes are the leading cause of death for people aged 16 to 19. PARENTS – warn your teenagers not to drive after using marijuana or other drugs, and not to get in a car with a driver who has used marijuana or other drugs! When teens’ driving inexperience is combined with the use of drugs that can affect cognitive and motor skills, the results can be tragic. Help protect your kids and your community this holiday season by helping to keep all impaired drivers off the roads.

Kelly Sickafoose is Secretary of the Northeast Regional Advisory Council of Community Anti-Drug Coalitions, Executive Director of Drug Free Adams County and Coordinator of Adams County Drug Court. She serves in an advisory capacity in LaGrange and Steuben counties. Contact her at [email protected]

read more
Prescription drugs

Marijuana use could make prescription drugs ineffective

Using marijuana may reduce the effectiveness of some common medications, including popular over-the-counter drugs and others used to treat breast cancer, according to an expert.

Dr Philip Lazarus, a pharmaceutical scientist at Washington State University, told UPI his team found in laboratory research that the use of marijuana can either overburden or even reduce , the effectiveness of drugs in a human system.

Common medications like Tylenol, Motrin – or other ibuprofens – or blood thinners could be too effective when interacting with marijuana and potentially harm the user.

On the other hand, an often used breast cancer drug can be rendered ineffective when it interacts with cannabis.

The results are worrisome, as many people use marijuana to relax and even manage pain. The use of the drug has become common in recent years, and research shows that it could cause harm to some people who need these drugs on a daily basis.

Marijuana could interact with certain pain relievers or drugs for the treatment of breast cancer in ways that could be dangerous. The drug interacts with Tylenol and Ibuprofen in a way that could damage the liver. For people who use the breast cancer drug tamoxifen, marijuana may reduce the drug’s effectiveness (file photo)

“We have seen significant inhibitions,” Lazarus told UPI.

“The concentrations that we see in the lab are probably an indicator that there is at least some inhibition of these enzymes in real time.”

They looked at how two chemicals found in marijuana, CBD and THC, interact with enzymes and other bodily functions that allow a person’s body to break down these chemicals.

Warfarin, for example, is a blood thinner often used by people with blood clots.

If the drug interacts with CBD, it becomes so effective that it can become dangerous.

– That one, you’re not joking with. Effects of too high a level, even transiently, for a few days can be fatal, ”University of Buffalo professor Ed Bednarczyk told UPI.

“It’s king of the hill for risk, because it’s everywhere in terms of patient-to-patient variability.”

Marijuana can also enhance the effects of ibuprofen. Although over-the-counter medications are generally safe in normal doses, they can become problematic for a person’s kidneys if overused.

When interacting with cannabis, ibuprofen or other pain relievers like Tylenol become extremely effective – almost too effective – and can damage the liver.

‘[Ibuprofen] is toxic to your liver and kidneys anyway, but you start taking marijuana on top of that, then you will see significant effects, ”Lazarus said.

“It would probably cause toxicity because you slow down its metabolism, which means you don’t excrete the substance and you have more of it in your body.”

Tamoxifen, a drug used to treat breast cancer, has the opposite interaction with marijuana.

Tylenol and other pain relievers could be commonly used, making marijuana use a potential danger for some (file photo)

Tylenol and other pain relievers could be commonly used, making marijuana use a potential danger for some (file photo)

Researchers have found that marijuana can negatively impact the enzymes a person’s body uses to break down drugs.

If the drug is not broken down enough in a person’s body, it will not get the full benefit of it, which will prevent the person from receiving the full amount of treatment they expect.

This can be all the more worrying given that many breast cancer patients using marijuana for pain management, and to relieve stress, while receiving treatment for their illness.

These findings are of concern to people who regularly use these drugs and consume marijuana, and Lazarus wants to further study these interactions between marijuana and prescription and over-the-counter drugs.

“We need to do clinical studies to show people that if you take a specific drug and also smoke a marijuana cigarette that morning, you see higher or lower levels of that drug in your body,” a- he declared.

The use of marijuana in the United States has increased dramatically in recent years as it slowly gains legalization and decriminalization across the country.

A study published earlier this year, which gathered data from 2017, found that more than 15% of Americans had used marijuana in the past year and that the number of people who used it daily had doubled between 2006 and 2016.

read more
Prescription drugs

DEA chief warns of fake prescription drugs containing fentanyl

WASHINGTON – Mexican drug cartels are flooding the U.S. market with fake prescription pills containing fentanyl, resulting in thousands of overdoses and deaths, according to the Drug Enforcement Administration (DEA).

During a press conference Thursday afternoon, DEA administrator Anne Milgram, JD, said that one morning in May this year, the parents of a 15-year-old freshman in high school in the ‘Idaho “found their son in his bedroom. He was not breathing. Although he started CPR right away and immediately called for help, their son died of a fentanyl overdose. “

The boy’s death was caused by a pill he bought on Snapchat – “a pill he thought was prescription oxycodone,” she continued. “It looked like a prescription oxycodone pill, but it wasn’t. It was actually a fake pill with a lethal dose of fentanyl in it.”

Deaths like this happen every day in the United States, Milgram said. “We know that these overdose deaths are directly caused by the Mexican drug cartels flooding the United States with millions of fake pills” containing large amounts of fentanyl powder. “Mexican drug networks get a lot of chemicals from China, then they mass produce – often in industrial labs – these lethal substances in Mexico, then pump that poison into the United States. And they are killing tens of thousands of Americans. “

“Equally disturbing is that the cartels have exploited the perfect drug delivery tool – social media apps that are available on every smartphone in the United States,” she said, adding that “85% of all Americans have smartphones … When you open Snapchat, when you open Facebook, when you open Instagram, when you open TikTok, when you open YouTube, drug dealers and criminal networks are waiting for you. “

The cartels “target people of all ages: a curious teenager ordering a pill online, a college student trying a friend’s pill, an elderly neighbor looking online for a pain reliever,” Milgram said. They use social media because “it’s widely available, it’s easy to use, and drug dealers can hide their identities … And most importantly, the sites allow the sale of these fake counterfeit pills every day without control”.

“These criminal drug networks distort what they sell,” she added. “People think they are buying real Xanax pills, real Adderall pills, real oxycodone using online platforms they trust, when in reality they are getting lethal fentanyl in pills that look like to the real thing. “

To tackle the problem, “Last Tuesday, just 2 days ago, the DEA completed a wave of public safety – our second since August – to target the most dangerous drug traffickers and drug networks. pushing deadly drugs in our country, “says Milgram.” Our investigations revealed that these networks were directly linked to 39 overdose deaths, and 76 of our investigations involved drug-related criminal activity on Facebook and Facebook Messenger, on Snapchat, Instagram, TikTok, YouTube and other social media platforms. “

In total, from September 29 to December 14, the agency seized more than 8.4 million fake pills, more than 5,400 pounds of methamphetamine and hundreds of pounds each of cocaine, heroin and marijuana, “often at the same places we grabbed the fentanyl, “she said. And 2 days before the press conference,” DEA agents in Arizona seized about 1.7 million pills and 13 pounds of fentanyl in one go . I have no doubts that DEA officers and Task Force officers have avoided a significant number of overdoses and overdoses. death with just this seizure. “

On September 27, the agency issued its first public safety alert in 6 years to warn people of fake pills. So far in 2021, the DEA had seized 9.5 million fake pills, more than in the previous 2 years combined.

Milgram urged the public to be part of the solution. “Know the dangers – and the accessibility – of deadly drugs online,” she said. “Never take drugs that have not been prescribed for you personally and filled by a licensed pharmacist. Spread the word that a pill can kill.”

  • Joyce Frieden oversees the coverage of MedPage Today in Washington, including articles about Congress, the White House, the Supreme Court, health professional associations and federal agencies. She has 35 years of experience in health policy. To follow

read more
Prescription drugs

Florida man sells mislabeled prescription drugs to Lubbock DEA officer

A Florida man admitted to selling mislabelled prescription drugs to an undercover Lubbock Drug Enforcement Administration agent.

Authorities learned of the existence of a Palm Beach, Florida, drug dealer identified as Albert Richard Boozer. An agent contacted Boozer in late 2019 and attempted to purchase pills. A deal was made and $ 800 was paid for 200 Adderall pills.

AllLubbock reports two separate packages were received by the authorities in February 2020. One package contained a vial of dietary supplement containing 192 Tramadol tablets. The other package was a bubble wrap containing 101 tablets, 97 of which were Tramadol.

Boozer used the website timbres.com with the alias “Ryan Smith” to send the contraband. This is how the authorities were able to identify Boozer.

A search warrant was granted to search for Boozer’s emails and they found emails detailing the reshipping of prescription drugs for an India-based company. During a search of Boozer’s home, several bottles of food supplements were found containing other substances.

The confession was part of a guilty plea agreement. To date, the judge has neither accepted nor rejected the plea.

SUBSCRIBE TO OUR NEWSLETTER TO RECEIVE ALL THE NEWS FROM THE SOUTHERN PLAINS

Expensive Airbnb stays in Lubbock, TX

5 Must-See Things About Lubbock If You Are Moving

8 of the most Lubbock things you can do

These are the most extremely Lubbock things to do.

Lubbock Etsy Artists We Love

read more
Prescription drugs

Study: Consumption of Cannabis with Prescription Drugs Could Raise “Significant Risk of Harmful Drug Interactions”

Metabolites in the blood of users appear to interfere with the metabolism of a wide range of prescribed drugs and could lead to toxicity or accidental overdose.

Content of the article

Researchers at Washington State University report that cannabis users who have also used other drugs to treat various conditions may reduce the effectiveness of those drugs.

Advertising

Content of the article

Investigators looking to determine possible drug interactions have found that the positive effects of the treatment drugs taken may decrease or that their negative effects may increase, explains a statement from the university.

If too much medicine builds up in the body, it could cause “unintended side effects such as toxicity or accidental overdose,” the researchers say.

  1. These are the first exemptions from the Controlled Drugs and Substances Act granted for mental health reasons by the new Minister of Health, Jean-Yves Duclos.  PHOTO BY REUTERS / BLAIR GABLE

    Exclusive: Three Canadians With Mental Disorders Have Legal Access To Psilocybin Mushrooms

  2. FILE: Military march organized in Canada after the body of a fallen soldier was repatriated in September 2009.

    Canadian poll: Anxiety or stress are the top reasons Canadian veterans report turning to medical cannabis

  3. A comparison of the exposed and control groups revealed that the former, immediately after the exposure period, had a decrease in sperm motility.  /

    Study: Exposure to cannabis vapors negatively affects mouse semen for two generations

To arrive at this point of view, investigators looked at cannabinoids – including THC, CBD, and CBN – and their major metabolites found in the blood of cannabis users. They used manipulated human kidney cells, allowing them to “examine one enzyme at a time.”

Advertising

Content of the article

According to the university’s statement, the researchers suggest that these cannabinoids and metabolites “interfere with two families of enzymes that help metabolize a wide range of drugs prescribed for various conditions.”

Possible toxicity is a real concern and something doctors should have on their radar, notes lead author Philip Lazarus.

This is especially the case when cannabis is used medicinally, suggests Lazarus. “It’s one thing if you’re young and healthy and smoke cannabis every now and then, but for older people who are on medication, taking CBD or medicinal marijuana can have a negative impact on their health. treatment, ”he warns.

The results are based on two studies published in Metabolism and elimination of drugs: one focused on the cytochrome P450 (CYP) family of enzymes, and the other on the UDP-glucuronosyltransferases (UGT) family of enzymes.

Advertising

Content of the article

“Together, these two families of enzymes help metabolize and eliminate from the body more than 70% of the most commonly used drugs,” the statement said.

Specifically, the researchers found that “cannabinoids and the major metabolites of THC strongly inhibited several CYP enzymes” and that “THC-COO-Gluc appears to play a major role in inhibiting several key enzymes in the liver.”

Regarding UGTs, the three aforementioned cannabinoids – but especially CBD – “inhibited two of the main UGT enzymes found in the liver. CBD was also found to block three enzymes that make up about 95% of UGT’s renal metabolism, which helps flush toxins and certain drugs from the body, ”the release notes.

“If you have kidney disease or if you take one or more drugs that are mainly metabolized by the kidneys and you also smoke marijuana, you may be inhibiting normal kidney function and this may have long term effects on your kidneys. you ”Lazarus warns.

Advertising

Content of the article

Possible toxicity is a real concern and something doctors should have on their radar.  /
Possible toxicity is a real concern and something doctors should have on their radar. / Photo by Getty Images

Calling the results the first to show the inhibitory potential of THC-COO-Gluc – the most abundant cannabinoid metabolite in plasma – researchers write in one of the studies that “the main cannabinoids and their metabolites present in the plasma of cannabis users inhibit several P450 enzymes”.

These enzymes “are involved in the synthesis and metabolism of a range of internal and external cellular components”, according to the medical life sciences.

Shamema Nasrin, the study’s first author, claims that the resulting metabolites created when cannabinoids break down in the body can last for up to 14 days and are in higher concentrations than cannabinoids. These are points, argues Nasrin, that “have been overlooked in previous studies, so we thought we should focus on these as well.”

Advertising

Content of the article

The study authors cite the legalization of cannabis in many parts of the United States and other countries as stressing the “need for a more complete understanding of the constituents of cannabis and their potential for drug interactions.”

As such, the university statement emphasizes that “it is important to be careful when using cannabis with other prescription drugs.”

“Taking CBD or marijuana may relieve your pain, but could make the other medicine you are taking more toxic, and this increase in toxicity may mean that you cannot continue taking this medicine,” says Nasrin.

“So there could be serious ramifications for anticancer drugs, and this is just one example of the many drugs that could potentially be affected by the cannabinoid-enzyme interactions that we are seeing,” she adds.

Authors of an Australian study exploring potential drug interactions with medicinal marijuana would likely agree. “Care should be taken to closely monitor the reactions of cannabis users to certain drugs to ensure their safety, especially for the elderly and those with chronic diseases or kidney and liver disease.” write the authors of the study published in 2019.

A see again in the Journal of the Canadian Medical Association last year there was an increase in the clearance of certain drugs among regular cannabis users. However, “no effects from occasional use have been reported.”

Advertising

Content of the article

We apologize, but this video failed to load.

To subscribe to Weekend dispensary , a new weekly newsletter from The GrowthOp.

    Advertising

    comments

    Postmedia is committed to maintaining a vibrant but civil discussion forum and encourages all readers to share their views on our articles. Comments may take up to an hour of moderation before appearing on the site. We ask that you keep your comments relevant and respectful. We have enabled email notifications. You will now receive an email if you receive a reply to your comment, if there is an update to a comment thread that you follow, or if a user that you follow comments. Visit our Community rules for more information and details on how to adjust your E-mail settings.

    read more
    Prescription drugs

    Hyperlipidemia Prescription Drug Market Outlook to 2026 by Application, End User and Geography

    The latest research report on Prescription Drug Market for Hyperlipidemia Informs the reader of all the important aspects that influence the behavior of the industry, such as the main growth drivers and challenges, to enable stakeholders to make informed decisions for the future. It also includes a comparison of past and current business scenarios to support the study’s forecast. In addition, the document offers a detailed account of the various market segments and recognizes the key areas that promise solid revenues in the years to come.

    According to industry experts, the hyperlipidemia prescription drug market size is expected to yield high profits over the period 2021-2026, registering a XX% CAGR throughout.

    Research literature uncovers the impact of the COVID-19 pandemic on this area, with a focus on barriers such as changes in customer behavior, supply chain flows, and imbalances in business operations . It also recommends various approaches that will ensure an upward growth trajectory in the years to come.

    Request a copy of this report @ https://www.nwdiamondnotes.com/request-sample/100872

    ImportantPointers of the Hyperlipidemia Prescription Drugs Market report:

    • COVID-19 Status and Its Impact on Industry Compensation
    • Market and submarkets growth rate approximations
    • Predominant trends in the vertical
    • Business expansion opportunities
    • Advantages and disadvantages of the indirect and direct sales channel
    • Main traders, suppliers and resellers

    Hyperlipidemia Drugs Market Segments Covered in Report:

    Geographic bifurcation: North America, Europe, Asia-Pacific, South America and Middle East & Africa

    • Review of the business landscape for each regional market at country level
    • Aggregate sales and revenue data for each area
    • Share of industry captured by major regional contributors
    • Estimates of the growth rate of each regional market over the evaluation period

    Product Types: HMG COA Reductase Inhibitors, Fibric Acid Derivatives, Nicotinic Acid, Bile Acid Sequestering Agents, Cholesterol Absorption Inhibitors, and Combination Drug Therapy

    • Sales, revenue and market share of each product segment
    • The pricing model for each product category

    Application spectrum: Hospital and Clinic

    • Global turnover and sales secured by each application segment
    • Product pricing according to scope

    Competitive dashboard:

    • Amgen
    • Eli lilly
    • GlaxoSmithKline Pharmaceuticals
    • Isis Pharma
    • Merck
    • Dr Reddy’s laboratories
    • Immuron Limited
    • Esperion Therapeutics
    • Pfizer and Formac Pharma

    • Products and services offered by the best companies
    • Leading organizations manufacturing facilities in the geographies served
    • Annals of price models, gross margins, sales, market share and cumulative revenue of major players
    • SWOT analysis of the main organizations
    • New emerging competitors in the market
    • Review of well-known trading tactics
    • Conclusive overview of market concentration rate and commercialization rate

    Purpose of Prescription Drugs for Hyperlipidemia: –

    To assess the value, market share, sales margin, hyperlipidemia drugs industry status (2016-2020) and forecast scenario (2021-2026).

    To study the main players of the drug Hyperlipidemia and their company profiles, their statistics of production, consumption and import-export

    To analyze the growth, opportunity, development, and risk of the Hyperlipidemia Drugs industry in various regions.

    To understand the competitive view of the market, SWOT and gross margin statistics.

    To present, describe, analyze, and define the Hyperlipidemia Drugs industry on the basis of product type, applications, and regions.

    To examine development plans, industry policies, market size, value, and sales of major players in Hyperlipidemia Prescription Drugs.

    Investigate crucial factors such as market risks, drivers, maturity analysis of prescription hyperlipidemia drugs.

    Table of contents overview:

    1. Hyperlipidemia Prescription Drug Market Overview
    2. Hyperlipidemia Prescription Drug Market Company Profiles
    3. Competition in the market, by players
    4. Market Size Segment by Type
    5. Market Size Segment by Application
    6. North America by Country, Type and Application
    7. Europe by country, type and application
    8. Asia-Pacific by Region, Type and Application
    9. South America by Country, Type and Application
    10. Middle East & Africa by Country, Type and Application
    11. Research results and conclusion.

    Request customization on this report @ https://www.nwdiamondnotes.com/request-for-customization/100872

    read more
    Prescription drugs

    Florida man admits selling mislabeled prescription drugs to infiltrate Lubbock DEA agent | KLBK | KAMC

    LUBBOCK, Texas – A Florida man admitted on Monday to selling mislabeled prescription drugs to an undercover Lubbock Drug Enforcement Administration agent, court records showed. The admission was part of a plea agreement.

    Albert Richard Boozer, of Palm Beach, Florida, was first contacted by an undercover DEA agent in Lubbock in late 2019, court documents show.

    Court documents say the officer contacted a suspected drug dealer and attempted to purchase 200 Adderall pills for $ 800. The trafficker agreed and the agent wired the money and provided a PO box where the trafficker could send the drugs.

    In February 2020, an envelope arrived with a bottle of the “Super Flex-6” dietary supplement, according to court documents. Inside the bottle were 192 pink circular tablets, which contained tramadol, a controlled narcotic.

    Court documents said later in the month that another envelope arrived at the secret post office box. It contained a smaller bubble envelope containing 101 pink tablets. A lab report said the package contained 97 tramadol tablets.

    While the packages were sent by “Ryan Smith,” Boozer was identified through a Stamps.com account he was using to ship the drugs, according to court documents.

    When investigators obtained a warrant to search his emails, they found several messages regarding the reshipment of prescription drugs for a company in India. Investigators also found several food supplement pill bottles containing pills when they collected garbage from her home. The pills were found to be controlled substances, according to court documents.

    On Monday, the guilty plea had not been accepted by a judge.

    read more
    Prescription drugs

    Is mixing cannabis and prescription drugs a good idea?

    It is well known that cannabis has many medicinal benefits, including the management of chronic pain, epilepsy, anxiety, and the treatment of symptoms of PTSD.

    However, in the case of cannabinoids, a group of substances found in the cannabis plant, there is a risk that its combination with other prescription drugs could lead to harmful drug interactions, new research from scientists at Washington State University (WSU) has suggested. .

    Researchers looked at cannabinoids and their main metabolites found in the blood of cannabis users and found that they interfere with two families of enzymes that help metabolize a wide range of drugs prescribed for various conditions. As a result, either the positive effects of the drugs might decrease, or their negative effects might increase with too much accumulation in the body, causing unintended side effects such as toxicity or accidental overdose.

    The results examined the interaction between three of the most abundant cannabinoids – tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN).

    While more research is essential, the authors suggested using caution when using cannabis with prescription drugs.

    “Physicians should be aware of the possibility of toxicity or a lack of response when patients use cannabinoids,” said Philippe Lazare, lead author of the article and Boeing Distinguished Professor of Pharmaceutical Sciences. “It’s one thing if you’re young and healthy and smoke cannabis every now and then, but for older people who are on medication, taking CBD or medicinal marijuana can have a negative impact on their health. processing. “

    Lazarus added, “It’s one thing if you’re young and healthy and smoke cannabis every now and then, but for older people who are on medication, taking CBD or medicinal marijuana can have a negative impact. negative impact on their treatment. “

    The results

    The researchers used manipulated human kidney cells and confirmed their results in human liver and kidney samples in which enzymes were present.

    Shamema nasrin, a graduate student from WSU College of Pharmacy and Pharmaceutical Sciences, pointed out that even though cannabinoids remain in the consumer’s body for about 30 minutes before being quickly broken down, the metabolites resulting from this process could remain in the system for up to 14 days.

    What’s more, the metabolites are also found “in higher concentrations than cannabinoids,” she explained, adding that they had been “overlooked in previous studies.”

    Potential negative drug interactions include a decrease in the positive effects of the drugs, as well as an increase in its negative effects resulting in excessive build-up in the body which could cause unintended side effects such as toxicity or accidental overdose.

    “Taking CBD or marijuana might ease your pain, but could make the other drug you’re taking more toxic, and this increase in toxicity may mean you can’t keep taking this drug,” Nasrin said. “So there could be serious ramifications for anticancer drugs, and this is just one example of the many drugs that could potentially be affected by the cannabinoid-enzyme interactions that we are seeing.”

    Authorities in Virginia Highlight Potential of Psychedelics in Treating Depression and PTSD

    What happens if you smoke weed every day?

    Photo: Courtesy of Talha Hassan to Unsplash

    read more
    Prescription drugs

    Does Medicare Cover Prescription Drugs?

    TThe good news is that when you are eligible for Medicare, you will also be able to purchase insurance that pays a portion of the costs of your prescription drugs – in many cases, most of the costs. But there are many caveats about Medicare drug coverage and significant variations in coverage and costs between plans.

    Original health insurance (parts A and B) does not cover prescription drugs except in special cases (drugs administered during surgery for example). Original Medicare beneficiaries are eligible to purchase prescription drug coverage, called Medicare, Part D, which is sold and administered by private insurers.

    More Advantage of Medicare plans, on the other hand, include coverage for prescription drugs.

    In both cases, Medicare Part D and Medicare Advantage, it is important to remember that the specific drugs covered vary from plan to plan. The same goes for monthly premiums and other fees. It is therefore beneficial to educate yourself, shop carefully and re-evaluate your choice of package each year.

    What Medicare Part D plans cover

    Medicare drug plans cover both generic and brand name drugs. All plans cover certain categories of drugs to treat specific conditions. Each plan decides which specific drugs to insure by category.

    Each Medicare Part D plan lists the drugs it covers on a formulary, which typically includes both brand name drugs and generic drugs. Forms change, so it is very important to regularly check that your medications are included.

    You should also check each plan for restrictions on drug coverage, such as requirements that certain drugs must be approved in advance by the insurer.

    If you or your provider thinks that none of the covered medications will adequately treat your condition, you can request a exception.

    What you will pay for prescriptions

    In addition to Part D premiums, you may be responsible for cost sharing, which may include deductibles, copayments, or coinsurance. Medicare Part D plans set their own premiums.

    Part D plan deductibles vary from $ 0 to the maximum allowed, which in 2021 is $ 445 (rising to $ 480 in 2022). Those with higher incomes will pay an additional monthly fee of $ 12.30 to $ 77.10 for Part D in 2021.

    Co-payments or coinsurance

    Almost all Medicare Part D and Medicare Advantage plans with prescription drug coverage charge a copayment or coinsurance. Buy with care; your costs will vary from plan to plan.

    Part D coverage requires you to pay varying prices for different categories of drugs. In general, your cost share will be higher for brand name drugs.

    Note that if you delay your Part D registration for too long, you will have to pay a late registration penalty.

    How To Compare Medicare Part D Plans

    Medicare.gov can help you find a Part D plan that covers your prescriptions and can help you compare your costs under various Medicare Part D and Medicare Advantage plans.

    More from NerdWallet

    John Rossheim writes for NerdWallet. Email: [email protected]

    Does the Medicare article cover prescription drugs? originally appeared on NerdWallet.

    The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

    read more
    1 2 3
    Page 2 of 3